The Basic Principles of Chimeric Antigen Receptor Design
نویسندگان
چکیده
منابع مشابه
The basic principles of chimeric antigen receptor design.
UNLABELLED Chimeric antigen receptors (CAR) are recombinant receptors that provide both antigen-binding and T-cell-activating functions. A multitude of CARs has been reported over the past decade, targeting an array of cell surface tumor antigens. Their biologic functions have dramatically changed following the introduction of tripartite receptors comprising a costimulatory domain, termed secon...
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ژورنال
عنوان ژورنال: Cancer Discovery
سال: 2013
ISSN: 2159-8274,2159-8290
DOI: 10.1158/2159-8290.cd-12-0548